• Table of Contents

  • The Role of HPMC K100M in Floating Drug Delivery Systems
  • What are Floating Drug Delivery Systems?
  • The Role of HPMC K100M in Floating Drug Delivery Systems
  • Benefits of Using HPMC K100M
  • Applications of HPMC K100M in Floating Drug Delivery Systems
  • Case Study: HPMC K100M in Omeprazole Floating Tablets
  • Conclusion

The Role of HPMC K100M in Floating Drug Delivery Systems

Hydroxypropyl methylcellulose (HPMC) is a widely used polymer in the pharmaceutical industry due to its excellent film-forming and gelling properties. HPMC K100M, in particular, has gained significant attention for its role in the development of floating drug delivery systems. This article explores the benefits and applications of HPMC K100M in floating drug delivery systems.

What are Floating Drug Delivery Systems?

Floating drug delivery systems are designed to prolong the gastric residence time of drugs in the stomach, thereby improving drug absorption and bioavailability. These systems are particularly useful for drugs that have a narrow absorption window or are poorly soluble in acidic environments.

The Role of HPMC K100M in Floating Drug Delivery Systems

HPMC K100M is a hydrophilic polymer that swells in the presence of water, forming a gel layer around the drug particles. This gel layer helps the drug to float on the gastric fluid, ensuring prolonged contact with the gastric mucosa. As a result, the drug is released slowly and steadily, leading to improved drug absorption.

Benefits of Using HPMC K100M

• Enhanced drug bioavailability
• Prolonged drug release
• Reduced dosing frequency
• Improved patient compliance

Applications of HPMC K100M in Floating Drug Delivery Systems

HPMC K100M is commonly used in the development of various floating drug delivery systems, including:

• Floating tablets
• Floating capsules
• Floating microspheres

Case Study: HPMC K100M in Omeprazole Floating Tablets

A study conducted on omeprazole floating tablets formulated with HPMC K100M demonstrated a significant increase in drug bioavailability compared to conventional tablets. The floating tablets showed sustained release of omeprazole over an extended period, leading to improved therapeutic outcomes.

Conclusion

HPMC K100M plays a crucial role in the development of floating drug delivery systems by enhancing drug bioavailability, prolonging drug release, and improving patient compliance. Its applications in floating tablets, capsules, and microspheres have shown promising results in various studies. As pharmaceutical researchers continue to explore innovative drug delivery technologies, HPMC K100M is likely to remain a key ingredient in the formulation of floating drug delivery systems.